The Hand of Vecna
The Hand was a desiccated, mummified left hand. In order to use its powers, the wielder needed to cut off his or her own left hand at the wrist and press the Hand of Vecna against the remainder of the arm. The artifact then magically grafted itself onto its wearer and became a functioning limb. Removing the Hand of Vecna invariably killed its wearer.
Powers
Once attuned to the Hand of Vecna, a creature changed its worldview towards a neutral evil disposition. The artifact granted supernatural strength to its wearer, as well as a boost of cold energy to spells and attacks dealt with a weapon held by it.
In addition, the Hand of Vecna allowed its wearer to cast the finger of death, sleep, slow, and teleport spells a limited number of times. It progressively regained its magic every dawn. Using the artifact to cast any spells caused it to demand its wearer to commit an evil act shortly thereafter, in a manner similar to the suggestion spell.
If both the Eye and the Hand were to be attuned to the same creature, the wearer enjoyed numerous additional benefits, such as immunity to disease and poison, premonitions of imminent danger, the ability to turn an opponent's skeleton into jelly by touching it with the Hand, regeneration powers, and the ability to cast wish once every 30 days.